You could use the access tag.
See here.
Maybe something like motor_vehicle=Su-Fr ?

Maybe somehow using the day_on and day_off Time restrictions?

I’m not sure it would be good enough, as you’d want to help the routing applications to avoid these area,
so I guess it should be on the ways themselves.

As a related issue, I guess your next question is how would one mark the Tchum Shabat? :wink:

talkat.